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- Title
Complex trait mapping in isolated populations: Are specific statistical methods required?
- Authors
Bourgain, Catherine; Génin, Emmanuelle
- Abstract
In this paper, we review the statistical methods that can be used in isolated populations to map genes involved in complex diseases. Our intention is to highlight the fact that if the features of population isolates may help in the identification of susceptibility factors for complex traits, the choice and design of methods for statistical analysis in these populations deserve particular care. We show that methods designed for outbred samples are generally not appropriate for isolated populations and could lead to false conclusions.European Journal of Human Genetics (2005) 13, 698-706. doi:10.1038/sj.ejhg.5201400 Published online 23 March 2005
- Subjects
GENES; HEALTH; CHROMOSOMES; BREEDING; HUMAN biology; HUMAN genetics
- Publication
European Journal of Human Genetics, 2005, Vol 13, Issue 6, p698
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/sj.ejhg.5201400