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- Title
Refractory status epilepticus secondary to Neurexin-3α encephalitis: A case report.
- Authors
Koh, S. J.; Ang, C. H.; Tham, H. L. C.; Chua, H. C.
- Abstract
New-onset refractory status epilepticus (NORSE) is a rare and challenging disease entity that is associated with high morbidity and mortality. Among the NORSE cases with a proven aetiology, autoimmune encephalitis has been identified as a leading cause. Here we describe a young man who presented with NORSE and was eventually found to have serum autoantibodies against Neurexin-3α, a synaptic molecule that has recently been implicated as a target in the pathogenesis of a novel form of autoimmune encephalitis. The patient's seizures responded to plasmapheresis, though the patient eventually died from sepsis. This case shows that Neurexin-3α encephalitis is a possible cause of NORSE, and plasmapheresis may be an effective treatment.
- Subjects
STATUS epilepticus; ENCEPHALITIS; AUTOIMMUNE diseases; NEUREXINS; PLASMAPHERESIS
- Publication
Neurology Asia, 2018, Vol 23, Issue 3, p273
- ISSN
1823-6138
- Publication type
Article