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- Title
Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1 -phosphate.
- Authors
D'Muniz Pereira, Humberto; Oliva, Glaucius; Garratt, Richard Charles
- Abstract
The article offers information on the study for new inhibitors for schistosoma mansoni causing Schistosomiasis. The study purified and crystallized the schistosoma mansoni purine nucleoside phosphorylase (Sm PNP), soaked it on solution consisting of ribose-1-phosphate, sodium acetate, and glycerol for 48 hours before collecting the data using x-ray diffraction. Result of the study provided evidence that improving the potency of PNP might be useful against schistosomiasis.
- Subjects
SCHISTOSOMIASIS; PURINE synthesis; SCHISTOSOMA mansoni; PHOSPHORYLASES; RIBOSE phosphates; SODIUM acetate; X-ray diffraction
- Publication
Journal of Synchrotron Radiation, 2011, Vol 18, Issue 1, p62
- ISSN
0909-0495
- Publication type
Article
- DOI
10.1107/S0909049510027718