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- Title
Prognostic Factors of Treatment Outcomes in Patients with Granulocytic Sarcoma.
- Authors
Tsung-Yu Lan; Dong-Tsamn Lin; Hwei-Fang Tien; Rong-Sen Yang; Chih-Yu Chen; Wu, Karl
- Abstract
Purpose: To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS). Methods: We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation. Results: The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028). Conclusion: Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes. Copyright © 2009 S. Karger AG, Basel
- Subjects
MYELOID leukemia; BONE marrow diseases; NONLYMPHOID leukemia; ACUTE myeloid leukemia; CHRONIC myeloid leukemia; PATIENTS
- Publication
Acta Haematologica, 2009, Vol 122, Issue 4, p238
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000253592