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- Title
Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products.
- Authors
Sadeqi Nezhad, Muhammad; Abdollahpour-Alitappeh, Meghdad; Rezaei, Behzad; Yazdanifar, Mahboubeh; Seifalian, Alexander Marcus
- Abstract
Chimeric antigen receptor T (CAR-T) cell therapy has been increasingly conducted for cancer patients in clinical settings. Progress in this therapeutic approach is hampered by the lack of a solid manufacturing process, T lymphocytes, and tumor-specific antigens. T cell source used in CAR-T cell therapy is derived predominantly from the patient's own T lymphocytes, which makes this approach impracticable to patients with progressive diseases and T leukemia. The generation of autologous CAR-T cells is time-consuming due to the lack of readily available T lymphocytes and is not applicable for third-party patients. Pluripotent stem cells, such as human induced pluripotent stem cells (hiPSCs), can provide an unlimited T cell source for CAR-T cell development with the potential of generating off-the-shelf T cell products. T-iPSCs (iPSC-derived T cells) are phenotypically defined, expandable, and as functional as physiological T cells. The combination of iPSC and CAR technologies provides an exciting opportunity to oncology and greatly facilitates cell-based therapy for cancer patients. However, T-iPSCs, in combination with CARs, are at the early stage of development and need further pre-clinical and clinical studies. This review will critically discuss the progress made in iPSC-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.
- Subjects
T cells; INDUCED pluripotent stem cells; PLURIPOTENT stem cells; CHIMERIC antigen receptors; DISEASE progression; THERAPEUTICS
- Publication
Pharmaceutical Research, 2021, Vol 38, Issue 6, p931
- ISSN
0724-8741
- Publication type
Article
- DOI
10.1007/s11095-021-03067-z