We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
EFFECT OF NATURAL HONEY ON HUMAN PLATELETS AND BLOOD COAGULATION PROTEINS.
- Authors
AHMED, ASIF; KHAN, RAFEEQ ALAM; AZIM, M. KAMRAN; SAEED, S. ARSHAD; MESAIK, M. AHMED; AHMED, SHAKIL; IMRAN, IMRAN
- Abstract
Present study was conducted to determine the effects of honey on blood hemostasis, in-vitro effect of honey was observed on platelet aggregation and blood coagulation employing, activated partial prothrombin time (aPTT), prothrombin time (PT), thrombin time (TT) and fibrinogen levels in blood. Honey samples showed moderate inhibition of platelet aggregation with IC50 5-7.5%. The coagulation assays showed that at higher concentrations (≥15%) honey samples increased whole blood clotting time. When assayed in platelet poor plasma (PPP), honey samples significantly (P≥0.005) prolonged aPTT, PT, and TT. The honey samples (at 3.75% and 7.5% concentrations) cause mean increment of aPTT = 19±10% and 62±10%; PT 6±5% and 40±5%; TT 35±15% and 112±30% respectively. Moreover, PPP isolated from whole blood pre-incubated with honey samples (9.0% for 10 minutes) showed mean prolongation of aPTT, PT and TT of 45±21%, 26±9% and 105±24% respectively. Interestingly, incubation of honey at 6.25% and 11.75% concentrations in PPP considerably (P≥0.005) reduced fibrinogen levels i.e. 13±4% and 86±30% respectively. The present study outlines the inhibitory effect of natural honey on platelet aggregation and blood coagulation. These observations provide first line data for modulatory role(s) of honey on process of hemostasis.
- Subjects
BLOOD coagulation; BLOOD platelet aggregation; BLOOD proteins; HONEY; HEMOSTASIS; PROTHROMBIN; FIBRINOGEN
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2011, Vol 24, Issue 3, p389
- ISSN
1011-601X
- Publication type
Article