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- Title
IN VITRO ANTIMICROBIAL ACTIVITY OF FOUR FICUS CARICA LATEX FRACTIONS AGAINST RESISTANT HUMAN PATHOGENS (ANTIMICROBIAL ACTIVITY OF FICUS CARICA LATEX).
- Authors
AREFI, HOUDA LAZREG; SALAH, KARIMA BEL HADJ; CHAUMONT, JEAN PIERRE; FEKIH, ABDELWAHEB; AOUNI, MAHJOUB; SAID, KHALED
- Abstract
Methanolic, hexanoïc, chloroformic and ethyl acetate extracts of Ficus carica latex were investigated for their in vitro antimicrobial proprieties against five bacteria species and seven strains of fungi. The green fruit latex was collected from Chott Mariam Souse, Middle East coast of Tunisia. The antimicrobial activity of the extracts was evaluated and based respectively on the inhibition zone using the disc - diffusion assay, minimal inhibition concentration (MIC) for bacterial testing and the method by calculating inhibition percentage (1%) for fungi-inhibiting activities. The methanolic extract had no effect against bacteria except for Proteus mirabilis while the ethyl acetate extract had inhibition effect on the multiplication of five bacteria species (Enterococcus fecalis, Citobacterfreundei, Pseudomonas aeruginosa, Echerchia coli and Proteus mirabilis). For the opportunist pathogenic yeasts, ethyl acetate and chlorophormic fractions showed a very strong inhibition (100%); methanolic fraction had a total inhibition against Candida albicans (100%) at a concentration of 500 μg/ml and a negative effect against Cryptococcus neoformans. Microsporum canis was strongly inhibited with methanolic extract (75%) and totally with ethyl acetate extract at a concentration of 750 μg/ml. Hexanoïc extract showed medium results.
- Subjects
PATHOGENIC microorganisms; CHLOROFORM; ANTI-infective agents; MICROSPORUM
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2010, Vol 23, Issue 1, p53
- ISSN
1011-601X
- Publication type
Article