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- Title
Melatonin in ICU delirium: shining light on the hormone of darkness.
- Authors
Burry, Lisa; Sonneville, Romain; Ely, E. Wesley
- Abstract
Although sleep-wake cycle disturbances are not a diagnostic criterion for delirium, they are incorporated into delirium assessment tools with studies indicating sleep alterations are present in 75% of delirious patients [[4]]. Previous randomized trials that explored the use of melatonin or melatonin receptor agonists for delirium prophylaxis in the ICU found mixed results (Table 1) [[10]-[14]]. Delirium represents a form of acute brain dysfunction predictive of excess death and long-term cognitive impairment in critically ill patients [[1]].
- Subjects
DELIRIUM; MELATONIN
- Publication
Intensive Care Medicine, 2022, Vol 48, Issue 4, p479
- ISSN
0342-4642
- Publication type
Editorial
- DOI
10.1007/s00134-022-06656-7