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- Title
Electrochemical C−H/N−H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles.
- Authors
Hou, Zhong-Wei; Mao, Zhong-Yi; Zhao, Huai-Bo; Melcamu, Yared Yohannes; Lu, Xin; Song, Jinshuai; Xu, Hai-Chao
- Abstract
Indoles and azaindoles are among the most important heterocycles because of their prevalence in nature and their broad utility in pharmaceutical industry. Reported herein is an unprecedented noble-metal- and oxidant-free electrochemical method for the coupling of (hetero)arylamines with tethered alkynes to synthesize highly functionalized indoles, as well as the more challenging azaindoles.
- Subjects
ELECTROCHEMISTRY; INDOLE compounds; CHEMICAL synthesis; AZAINDOLES; PHARMACEUTICAL industry; AROMATIC amines
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 32, p9168
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201602616