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- Title
An Epitope‐Specific Respiratory Syncytial Virus Vaccine Based on an Antibody Scaffold.
- Authors
Luo, Xiaozhou; Liu, Tao; Wang, Ying; Jia, Haiqun; Zhang, Yuhan; Caballero, Dawna; Du, Juanjuan; Wang, Rongsheng E.; Wang, Danling; Schultz, Peter G.; Wang, Feng
- Abstract
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in children. We have generated an epitope‐specific RSV vaccine by grafting a neutralizing epitope (F‐epitope) in its native conformation into an immunoglobulin scaffold. The resulting antibody fusion exhibited strong binding affinity to Motavizumab, an RSV neutralizing antibody, and effectively induced potent neutralizing antibodies in mice. This work illustrates the potential of the immunoglobulin molecule as a scaffold to present conformationally constrained B‐cell epitopes.Vaccine scaffolds based on antibody‐epitope fusions: Fusion of a virus‐neutralizing epitope (green) into the complementarity‐determining region (CDR) or constant loops of an immunoglobulin provides a strategy for generating epitope‐focused vaccines.
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 48, p14531
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201507928