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- Title
A Eu<sup>II</sup>‐Containing Cryptate as a Redox Sensor in Magnetic Resonance Imaging of Living Tissue.
- Authors
Ekanger, Levi A.; Polin, Lisa A.; Shen, Yimin; Haacke, E. Mark; Martin, Philip D.; Allen, Matthew J.
- Abstract
The EuII ion rivals GdIII in its ability to enhance contrast in magnetic resonance imaging. However, all reported EuII‐based complexes have been studied in vitro largely because the tendency of EuII to oxidize to EuIII has been viewed as a major obstacle to in vivo imaging. Herein, we present solid‐ and solution‐phase characterization of a EuII‐containing cryptate and the first in vivo use of EuII to provide contrast enhancement. The results indicate that between one and two water molecules are coordinated to the EuII core upon dissolution. We also demonstrate that EuII‐based contrast enhancement can be observed for hours in a mouse.EuII goes in vivo: Solid‐ and solution‐phase characterization of the coordination environment of a europium(II)‐containing cryptate are presented. This complex is employed in the measurement of the first in vivo images of contrast enhancement provided by a EuII‐based contrast agent for magnetic resonance imaging.
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 48, p14398
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201507227