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- Title
Copper-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes.
- Authors
Lou, Yazhou; Cao, Peng; Jia, Tao; Zhang, Yongling; Wang, Min; Liao, Jian
- Abstract
Presented is the first enantioselective copper-catalyzed 1,6-conjugate addition of bis(pinacolato)diboron to para-quinone methides. The reaction proceeds with excellent yields and good to excellent enantioselectivities, and provides an attractive approach to the construction of optically active gem-diarylmehtine boronic esters. Additionally, the subsequent conversion of the derived potassium trifluoroborates into triarylmethanes with highly enantiospecificity was realized.
- Subjects
ENANTIOSELECTIVE catalysis; COPPER analysis; QUINONE methides; DIARYL compounds; ANALYTICAL chemistry; BORON; BORONIC esters
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 41, p12134
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201505926