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- Title
Detection of Highly Pathogenic Avian Influenza Virus H5N1 in Peripheral Blood Mononuclear Cells and Stool of a Patient.
- Authors
Yan Liu; Rongbao Gao; Wanfu Hu; Mingying Ma; Wei Wang; Jun He; Jianjun Wang; Dexin Li; Yuelong Shu
- Abstract
A fatal case caused by an H5N1 virus infection was investigated. In addition to serials of clinical chemistry assays, we tested the patient's peripheral blood mononuclear cells (PBMC) and stool by reverse transcription polymerase chain reaction (RT-PCR), real-time RT-PCR, and/or immunofluorescent assay. Our results suggested that PBMC can carry the virus and help the H5N1 virus spread to the human gut, resulting in infection with inflammation and viral discharge.
- Subjects
CHINA; AVIAN influenza diagnosis; FECAL analysis; AVIAN influenza; BIOPHYSICS; BLOOD cell count; BLOOD cells; CLINICAL chemistry; FLUORESCENT antibody technique; RESEARCH methodology; POLYMERASE chain reaction; RESEARCH funding; URINALYSIS; VIRAL load; REVERSE transcriptase polymerase chain reaction; INFLUENZA A virus, H5N1 subtype; INFECTIOUS disease transmission
- Publication
Laboratory Medicine, 2011, Vol 42, Issue 5, p310
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1309/LMNSG3BK6GVTDAK1