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- Title
Suspension of Short‐lasting, Unilateral, Neuralgiform headache attacks with Conjunctival injection and Tearing (SUNCT) symptoms with ayahuasca and serotonergic psychedelics.
- Authors
Leighton, Jonathan; Petignat, Cyril; McGeeney, Brian E.
- Abstract
Plain Language Summary: A suicidal patient with Short‐lasting Unilateral Neuralgiform headache attacks with Conjunctival injection and Tearing (SUNCT) whose excruciating condition did not respond to various treatments discovered that ayahuasca, a psychoactive concoction used by indigenous populations of South America, caused his attacks to cease entirely. Inhaled N,N‐dimethyltryptamine (DMT), the principal psychoactive component of ayahuasca, also caused symptoms to disappear temporarily, as did a strong dose of lysergic acid diethylamide (LSD). This case study supports the potential of serotonergic psychedelics for the treatment of SUNCT and related headache disorders.
- Subjects
TRADITIONAL medicine; SEROTONIN agonists; LSD (Drug); HEADACHE; BRAIN; HALLUCINOGENIC drugs; MAGNETIC resonance imaging; PLANT extracts; SUNCT syndrome; MAGNETIC resonance angiography; TRYPTAMINE; LEAVES
- Publication
Headache: The Journal of Head & Face Pain, 2024, Vol 64, Issue 5, p595
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/head.14722