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- Title
Pentraxin 3 and other inflammatory biomarkers related to atrial fibrillation in cardiac surgery.
- Authors
Holubcova, Zdenka; Kunes, Pavel; Mandak, Jiri; Vlaskova, Dana; Kolackova, Martina; Holmannova, Drahomira; Andrys, Ctirad; Krejsek, Jan; Holubec, Tomas
- Abstract
Objectives: The aim was to evaluate the association between perioperative inflammatory biomarkers and atrial fibrillation (AF) in cardiac surgical patients. Methods: Forty-two patients undergoing cardiac surgery were divided into three groups according to the occurrence of AF: Group A (n = 22) - patients with no AF, Group B (n = 11) - patients with new onset AF postoperatively and Group C (n = 9) - patients with preoperative history of atrial fibrillation. The serum levels of PTX3, CRP, TLR2, IL-8, IL-18, sFas, MMP-7 and MMP-8 were measured at the following time points: before surgery, immediately and 6 h after surgery and on the 1st, 3rd and 7th postoperative days (POD). Results: Serum levels of PTX3 showed a significant difference between Groups A and C on the 3rd POD (p<0.05) and on the 7th POD (p<0.0001). IL-8 levels were different between Groups A and C immediately after surgery (p<0.05), 6 hours after surgery (p<0.05) and on the 3rd POD (p<0.05). There was a difference between Groups B and C on the 1st POD in IL-8 levels (p<0.05). The sFas levels differed between Groups A and C on the 3rd POD (p<0.01) and the 7th POD (p<0.05). There was also a difference on the 7th POD (p<0.05) between the Groups B and C. No significant differences between the groups was seen for other biomarkers. Conclusion: This study demonstrates significantly different dynamics of PTX3, IL-8 and sFas levels after cardiac surgery in relation to AF.
- Subjects
ATRIAL fibrillation; BIOMARKERS; CHI-squared test; STATISTICAL correlation; ENZYME-linked immunosorbent assay; FISHER exact test; CARDIAC surgery; INFLAMMATION; RESEARCH funding; STATISTICS; DATA analysis; MATRIX metalloproteinases; KRUSKAL-Wallis Test; ONE-way analysis of variance
- Publication
Perfusion, 2017, Vol 32, Issue 4, p269
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659116679248