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- Title
Krytyczna ocena randomizowanych badań klinicznych w gastroenterologii.
- Authors
Hartleb, Marek
- Abstract
Clinical studies involve observational surveys and randomized clinical trials (RCT), which evaluate an efficacy of new medical interventions. Subjects participating in RCTs undergo either experimental or control medical intervention. Most serious dangers for reliability of RCT are non-random systematic errors, having a potential to entirely distort final conclusions. These errors may occur on each stage of RCT and are usually result of improper design of the study, opening a possibility of biased assessment of therapeutic effect either by investigator or subject. RCT factors preventing from non-random systematic errors are randomized and concealed allocation of patients, double-blind intervention and "intended to treat" analysis of data, looking at number of patients lost from follow-up.
- Subjects
SCIENTIFIC observation; CLINICAL trials; CLINICAL medicine research; RANDOMIZED controlled trials; MEDICAL experimentation on humans
- Publication
Gastroenterologia Polska / Gastroenterology, 2007, Vol 14, Issue 4, p283
- ISSN
1232-9886
- Publication type
Article