We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gallotannins and Tannic Acid: First Chemical Syntheses and In Vitro Inhibitory Activity on AlzheimerÏs Amyloid b-Peptide Aggregation.
- Authors
Sylla, Tahiri; Pouységu, Laurent; Da Costa, Grégory; Deffieux, Denis; Monti, Jean-Pierre; Quideau, Stéphane
- Abstract
The screening of natural products in the search for new lead compounds against AlzheimerÏs disease has unveiled several plant polyphenols that are capable of inhibiting the formation of toxic β-amyloid fibrils. Gallic acid based gallotannins are among these polyphenols, but their antifibrillogenic activity has thus far been examined using "tannic acid", a commercial mixture of gallotannins and other galloylated glucopyranoses. The first total syntheses of two true gallotannins, a hexagalloylglucopyranose and a decagalloylated compound whose structure is commonly used to depict "tannic acid", are now described. These depsidic gallotannins and simpler galloylated glucose derivatives all inhibit amyloid β-peptide (Aβ) aggregation in vitro, and monogalloylated a-glucogallin and a natural β-hexagalloylglucose are shown to be the strongest inhibitors.
- Subjects
GALLOTANNIN; TANNINS; CHEMICAL synthesis; AMYLOID; PLANT polyphenols
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 28, p8217
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201411606