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- Title
Mild Bioconjugation Through the Oxidative Coupling of ortho-Aminophenols and Anilines with Ferricyanide.
- Authors
Obermeyer, Allie C.; Jarman, John B.; Netirojjanakul, Chawita; El Muslemany, Kareem; Francis, Matthew B.
- Abstract
Using a small-molecule-based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o-aminophenols on protein substrates. This reaction is compatible with thiols and 1,2-diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.
- Subjects
FERRICYANIDES; ANILINE synthesis; AMINOPHENOL synthesis; BIOCONJUGATES; OXIDATIVE coupling; THIOL synthesis; GLYCOL synthesis; BIOTECHNOLOGY research
- Publication
Angewandte Chemie International Edition, 2014, Vol 53, Issue 4, p1057
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201307386