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- Title
Effect of indomethacin on closure of ductus arteriosus in very-low-birthweight neonates1Presented at the Annual Meeting of the Canadian Paediatric Society, Montreal, Canada, 2004.
- Authors
Godambe, Sunit; Newby, Brandi; Shah, Vibhuti; Shah, Prakesh S.
- Abstract
Aim: To identify factors related to indomethacin non-responsiveness for patent ductus arteriosus (PDA) closure in very-low-birthweight (VLBW) neonates. Methods: A chart review of 107 VLBW neonates with a clinical diagnosis of PDA who received indomethacin, admitted to a tertiary neonatal intensive care unit in Toronto, Canada, was conducted (study period November 2001 to October 2003). Positive responders were those with no clinical evidence of PDA for 72 h after indomethacin. Results: Response to the first course of indomethacin was 75%, and to the second course 67% among initial responders. Higher CRIB score (OR 1.15, 95% CI 1.02–1.31) and early surfactant administration (OR 3.74, 95% CI 1.04–13.47) were associated with non-responsiveness to indomethacin.Conclusion: Indomethacin is effective for PDA closure. The response rate diminished with subsequent courses. Early surfactant and severity of illness at admission were associated with non-responsiveness to indomethacin.
- Subjects
INDOMETHACIN; PATENT ductus arteriosus; LOW birth weight; NEWBORN infants; NEONATAL intensive care; GESTATIONAL age; RESPIRATORY therapy for newborn infants; PREMATURE infants; PEDIATRICS; DIAGNOSIS; THERAPEUTICS
- Publication
Acta Paediatrica, 2006, Vol 95, Issue 11, p1389
- ISSN
0803-5253
- Publication type
Article
- DOI
10.1080/08035250600615150