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- Title
Oral Administration of Forskolin, Homotaurine, Carnosine, and Folic Acid in Patients with Primary Open Angle Glaucoma: Changes in Intraocular Pressure, Pattern Electroretinogram Amplitude, and Foveal Sensitivity.
- Authors
Mutolo, Maria Giulia; Albanese, Giuseppe; Rusciano, Dario; Pescosolido, Nicola
- Abstract
<bold>Purpose: </bold>To evaluate the effects of a food supplement containing forskolin, homotaurine, carnosine, folic acid, vitamins B1, B2, B6, and magnesium in patients with primary open angle glaucoma (POAG) already in treatment and compensated by intraocular pressure (IOP)-lowering drugs, during a period of 12 months.<bold>Methods: </bold>Twenty-two patients (44 eyes) with POAG, with their IOP compensated by topical drugs, were enrolled and randomly assigned to the food supplement or control treatment group. The additional food supplement treatment consisted of 2 tablets per day (1 in the morning, 1 in the evening) given for 1 year of a balanced association of homotaurine, Coleus forskohlii root extract, L-carnosine, folic acid, vitamins B1, B2, B6, and magnesium. Pattern Electroretinogram (PERG) amplitude, foveal sensitivity obtained with the visual field analyzer frequency doubling technology, and IOP were detected at enrollment (T0), 3 months (T1), 6 months (T2), 9 months (T3), and 12 months (T4).<bold>Results: </bold>We observed in treated patients a significant further decrease of IOP and an improvement of PERG amplitude at 6, 9, and 12 months, and foveal sensitivity at 12 months. All values remained substantially stable in control patients.<bold>Conclusions: </bold>The results of the present pilot study indicate that the components of the food supplement reach the eye in a detectable manner, as evidenced by the effects on the IOP. Moreover, they suggest a short-term neuroactive effect, as indicated by the improvement of PERG amplitude and foveal sensitivity in treated, but not in control patients.
- Subjects
OPEN-angle glaucoma; FORSKOLIN; ORAL medication; CARNOSINE; THERAPEUTIC use of folic acid; INTRAOCULAR pressure; ELECTRORETINOGRAPHY; DIAGNOSIS; THERAPEUTICS; ALKANES; ANTICONVULSANTS; COMPARATIVE studies; DIETARY supplements; FOLIC acid; GLAUCOMA; RESEARCH methodology; MEDICAL cooperation; ORAL drug administration; RESEARCH; RETINA; TERPENES; VASODILATORS; VITAMIN B complex; EVALUATION research; RANDOMIZED controlled trials; CASE-control method
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2016, Vol 32, Issue 3, p178
- ISSN
1080-7683
- Publication type
journal article
- DOI
10.1089/jop.2015.0121