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- Title
Clinical characteristics and in vitro susceptibility profiling of Candidemia in febrile neutropenic patients; a brief report in Tehran, Iran.
- Authors
Lotfali, Ensieh; Yadegarynia, Davood; Yousefi, Maysam; Ghajari, Ali; Arab-Mazar, Zahra; Ansari, Saham
- Abstract
Introduction: Febrile neutropenic patients are at risk of serious infections. Generally, bacteria are responsible for bloodstream infections (BSIs), but, 8% of all cases of infectious agents are Candida spp. Species of Candida that cause candidemia are the fourth most common agent of BSIs and the fifth most common cause of nosocomial infection. Candida albicans is the most important cause of BSIs; however 45%are caused by non-albicans species. The aim of the present study was to identify the frequency, species, and susceptibility patterns of candidemia in febrile neutropenic patients. Materials and Methods: This crosssectional study was conducted on febrile neutropenic patients suspected with candidemia who had been referred to 3 educational hospitals during 9 months of the study. Result: The blood samples of 80 febrile neutropenic patients with the mean age of 48±16.6 years were studied (60% female). Five (6.25%) episodes of candidemia were identified. The underlying disease was acute myeloid leukemia in 4 (80%) cases and all 5(100%) cases had central venous catheter and were receiving prophylactic ciprofloxacin and acyclovir. 100% of isolates were found to be susceptible to voriconazole, 80% to caspofungin, 60% to Amphotericin B, and 40% to fluconazole. Conclusion: The frequency of candidemia among the studied febrile neutropenia patients was 6.25%, with 80% mortality rate, and the most frequently identified yeast was Candida albicans (100% susceptible to Voriconazole).
- Subjects
IRAN; CONFERENCES &; conventions; FEBRILE neutropenia; MICROBIAL sensitivity tests; SYMPTOMS; CANDIDEMIA
- Publication
Current Medical Mycology, 2018, Vol 4, p90
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180