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- Title
Significance of chromosome 14 anomaly at band 14q11 in Japanese patients with adult T-cell leukemia.
- Authors
Sadamori, Naoki; Nishino, Kenji; Kusano, Miyuki; Tomonaga, Yu; Tagawa, Masuko; Yao, Ei-ichi; Sasagawa, Ippei; Nakamura, Hideo; Ichimaru, Michito; Sadamori, N; Nishino, K; Kusano, M; Tomonaga, Y; Tagawa, M; Yao, E; Sasagawa, I; Nakamura, H; Ichimaru, M
- Abstract
The chromosomes of leukemic blood cells in eight Japanese patients with acute adult T-cell leukemia (ATL) were examined by a direct method or short-term culture method without any mitogens. Six patients showed a chromosome 14 anomaly with a break at band q11-13: inv(14)(q11q32) in two patients, t(11;14)(p13;q13) in one patient, t(14;14)(q11;q32) in addition to del(14)(q11q13) in another, and only del(14)(q11q13) in two patients. Thus, a proximal 14q rearrangement exists in ATL as in other types of T-cell malignancies. Based on these facts, the pathogenesis of ATL is discussed in reference to the literature.
- Publication
Cancer (0008543X), 1986, Vol 58, Issue 10, p2244
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19861115)58:10<2244::AID-CNCR2820581014>3.0.CO;2-T