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- Title
Myelodysplastic syndrome or acute myeloid leukemia? A study of 28 cases presenting with borderline features.
- Authors
Scoazec, Jean-Yves; Imbert, Michèle; Crofts, Marilyn; Jouault, Hélène; Juneja, Surender K.; Vernant, Jean-Paul; Sultan, Claude; Scoazec, J Y; Imbert, M; Crofts, M; Jouault, H; Juneja, S K; Vernant, J P; Sultan, C
- Abstract
Some patients present borderline features between acute myeloid leukemia (AML) and typical myelodysplastic syndromes (MDS): an excess of blasts insufficient to conclusively diagnose AML, yet above the figures usually compatible with MDS or the presence of Auer rods associated with a moderate excess of blasts. This presents considerable difficulties in diagnosis and management. The authors studied 28 such cases using the French-American-British Co-operative Group (FAB) classification, which groups them into a separate category termed "refractory anemia with excess of blasts in transformation" (RAEB-T). This was found to be a heterogenous group. Certain patients (4/28) had a previously established myelodysplasia, but most presented directly as RAEB-T. Two very different pictures emerged: a few patients (4/28) were young, with presentation and evolution similar to classic AML, for whom combination chemotherapy was effective; the majority (20/28) were older, with more varied clinical and cytologic presentation, for whom chemotherapy was of little effect and who presented a picture resembling classic RAEB with a median survival of 10 months.
- Subjects
ANTINEOPLASTIC agents; ACUTE myeloid leukemia diagnosis; APLASTIC anemia; BONE marrow; DIFFERENTIAL diagnosis; ACUTE myeloid leukemia; RETROSPECTIVE studies
- Publication
Cancer (0008543X), 1985, Vol 55, Issue 10, p2390
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19850515)55:10<2390::AID-CNCR2820551015>3.0.CO;2-B