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- Title
Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium.
- Authors
Konno, Toshimitsu; Maeda, Hiroshi; Iwai, Ken; Maki, Shojiro; Tashiro, Seiki; Uchida, Mitsukuni; Miyauchi, Yoshimasa; Konno, T; Maeda, H; Iwai, K; Maki, S; Tashiro, S; Uchida, M; Miyauchi, Y
- Abstract
Twenty-four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic macromolecular drug, copoly(styrene-maleic acid) conjugated neocarzinostatin (SMANCS). The drug was dissolved in a lipid contrast medium Lipiodol and administered by catheterizing the respective feeding arteries under x-ray monitoring. The advantages of this therapy include: (1) selective deposition of Lipiodol with the anti-cancer drug in the target tumor, (2) a pronounced and long-lasting anti-cancer effect, (3) enhanced visualization of the tumor on x-ray examinations for a prolonged period which also facilitated the long-term follow-up, (4) semiquantitative evaluation of the dosage regimen by x-ray examination before further administration, (5) general applicability due to procedural simplicity, and (6) little side effect. Since the amount of Lipiodol and SMANCS used per administration for a patient (1.0-5.0 ml; 1.0-5.0 mg) was far less than the anticipated toxicity (LD50 of Lipiodol = 95 ml/60 kg, dog, intravenously; and that of SMANCS = 3.4 mg/kg, mouse, IV), no deleterious effects to such critical organs as the brain, heart, lung, liver, or kidneys were observed upon radiologic and general clinical examination.
- Publication
Cancer (0008543X), 1984, Vol 54, Issue 11, p2367
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19841201)54:11<2367::AID-CNCR2820541111>3.0.CO;2-F