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- Title
Asymmetric effects of low doses of progesterone on GABA(A) receptor α4 subunit protein expression in the olfactory bulb of female rats.
- Authors
Arbo, Bruno D.; Andrade, Susie; Osterkamp, Gabriela; Gomez, Rosane; Ribeiro, Maria Flávia
- Abstract
The aim of this study was to evaluate the effect of progesterone on the protein expression of α4 subunit of GABA(A) receptor, serotonin transporter (SERT), Akt, Erk, and caspase-3 in the olfactory bulb (OB) of female rats exposed to the forced swimming test (FST). Female rats were injected daily with progesterone (0.4 mg/kg body mass) or vehicle during 2 complete oestrous cycles and exposed to the FST, and the protein expression of GABA(A) receptor α4 subunit, SERT, Akt, Erk, and caspase-3 in the OB were evaluated. Progesterone increased the expression of the α4 subunit in the right OB and decreased its expression in the left OB, although it did not change the expression of other proteins. In summary, our findings indicate that progesterone has an asymmetric modulatory effect on the expression of GABA(A) receptor α4 subunit in the OB. This effect could be related to the antidepressant-like effect of progesterone in female rats.
- Subjects
PROGESTERONE receptors; GABA; OLFACTORY bulb; SEROTONIN transporters; BODY mass index
- Publication
Canadian Journal of Physiology & Pharmacology, 2014, Vol 92, Issue 12, p1045
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2014-0307