We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Exercise and nutrition in myocardial matrix metabolism, remodeling, regeneration, epigenetics, microcirculation, and muscle<sup>1</sup>.
- Authors
Tyagi, Suresh C.; Joshua, Irving G.
- Abstract
Remodeling and myocardial matrix metabolism contributes to cardiac endothelium-myocyte (perivascular fibrosis), myocyte-myocyte (interstitial fibrosis), and mitochondrion-myocyte (fusion and fission) coupling. Matrix metalloproteinases (MMPs), and tissue inhibitor of metalloproteinases (TIMPs) play differential roles in different tissues and diseases. For example, although present in the heart, MMP-3 is known as stromelysin (i.e., stromal tissue enzyme). Interestingly, TIMP-3 causes apoptosis. Exercise and nutrition are synergistic in the mitigation of diseases: exercise releases exosomes containing miRNAs. Nutrition/vitamins B6 and B12 regulate the metabolism of homocysteine (an epigenetic byproduct of DNA/RNA/protein methylation). Thus, epigenetic silencing is an important therapeutic target. The statistical analysis of cohorts may be less indicative for the treatment of a disease, particularly if the 2 twins are different in terms of responding to the medicine for the same disease, therefore, personalized medicine is the future of therapy.
- Subjects
NUTRITION; EXERCISE; CARDIOMYOPATHIES; EPIGENETICS; MICROCIRCULATION
- Publication
Canadian Journal of Physiology & Pharmacology, 2014, Vol 92, Issue 7, p521
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2014-0197