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- Title
Red blood cell transfusion-transmitted acute hepatitis E in an immunocompetent subject in Europe: a case report.
- Authors
Riveiro‐Barciela, Mar; Sauleda, Silvia; Quer, Josep; Salvador, Fernando; Gregori, Josep; Pirón, María; Rodríguez‐Frías, Francisco; Buti, Maria
- Abstract
<bold>Background: </bold>Acute hepatitis E in industrialized countries is usually related to intake or manipulation of undercooked or raw meat. Cases of transfusion-transmitted hepatitis E have rarely been documented in immunosuppressed patients, mainly after receiving frozen plasma.<bold>Study Design and Methods: </bold>A 61-year-old man was admitted to hospital for jaundice. His personal history included disseminated bacillus Calmette-Guerin infection treated with antituberculous drugs. He had received red blood cell (RBC) transfusion 2 months previously, during admission for mycotic aneurysm surgery. Since liver function tests worsened despite stopping antituberculous drugs, other causes of acute hepatitis were explored.<bold>Results: </bold>Acute hepatitis E was diagnosed by the presence of both immunoglobulin M and hepatitis E virus (HEV) RNA. Traceback procedure for the 8 RBC units was carried out, and one of the eight archive plasma samples tested positive for HEV RNA, with an estimated viral load of 75,000 IU/mL. Phylogenetic analysis revealed the same HEV strain Genotype 3 in one of the transfused RBC products and in the patient's serum sample.<bold>Conclusion: </bold>Transfusion of RBCs with detectable HEV RNA is a risk factor for acute hepatitis E in immunocompetent patients in Europe.
- Subjects
EUROPE; HEPATITIS E virus; RED blood cell transfusion; HEPATITIS E; TORQUE teno virus; POPULATION; ANEURYSM treatment; TUBERCULOSIS microbiology; TUBERCULOSIS treatment; ANEURYSMS; HEPATITIS viruses; MYCOBACTERIUM; RNA; TUBERCULOSIS; VIRAL antibodies; ACUTE diseases; INFECTIOUS disease transmission
- Publication
Transfusion, 2017, Vol 57, Issue 2, p244
- ISSN
0041-1132
- Publication type
case study
- DOI
10.1111/trf.13876