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- Title
Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women.
- Authors
Johnson, Courtney E.; Alberg, Anthony J.; Bandera, Elisa V.; Peres, Lauren C.; Akonde, Maxwell; Collin, Lindsay J.; Cote, Michele L.; Hastert, Theresa A.; Hébert, James R.; Peters, Edward S.; Qin, Bonnie; Terry, Paul; Schwartz, Ann G.; Bondy, Melissa; Epstein, Michael P.; Mandle, Hannah B.; Marks, Jeffrey R.; Lawson, Andrew B.; Schildkraut, Joellen M.
- Abstract
Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women.
- Publication
British Journal of Cancer, 2023, Vol 129, Issue 7, p1119
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/s41416-023-02385-w