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- Title
Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?
- Authors
Parra-Soto, Solange; Ho, Frederick K.; Pell, Jill P.; Celis-Morales, Carlos
- Abstract
<bold>Background: </bold>Whether the association of height with cancers differs by insulin-like growth factors has not been fully elucidated. Therefore, this study aimed to investigate the sex-specific associations between height and 24 site-specific cancers and to assess whether the association differed by IGF-1.<bold>Methods: </bold>In total, 414,923 participants from the UK Biobank prospective cohort study were included. The association of height (per 5-cm increment) with incidence and mortality from 24 cancer sites was investigated by using Cox proportional hazard models.<bold>Results: </bold>The median follow-up was 6.0 years. In men, height was positively associated with incidence risk of all-cause cancer and at five sites (lung, lymphatic, leukaemia, non-Hodgkin lymphoma and melanoma). In women, it was associated with breast, melanoma, lymphatic, non-Hodgkin lymphoma and all-cause cancer. The association was stronger in women than men for all-cause cancer incidence. The strength of the association did not differ by IGF-1 concentration.<bold>Conclusions: </bold>Adult height was associated with risk of several cancer sites. However, some of these associations were sex-specific. There was no strong evidence to support IGF-1 moderating the association between height and cancer.
- Publication
British Journal of Cancer, 2020, Vol 123, Issue 11, p1697
- ISSN
0007-0920
- Publication type
journal article
- DOI
10.1038/s41416-020-01059-1