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- Title
Chromosomal breaks: another differential gap between early-onset and late-onset colorectal cancers.
- Authors
Perea, José; García, Juan Luis; Corchete, Luis A; Martí, Marc; Hernández-Villafranca, Sergio; Alcázar, José A; Álvaro, Edurne; Hurtado, Elena; Jiménez-Toscano, Marta; Balaguer, Francesc; Ballestero, Araceli; López-Rojo, Irene; Jiménez, Fernando; Sanz, Gonzalo; Melone, Sirio; Brandáriz, Lorena; Vivas, Alfredo; Alvarellos, Alicia; González-Sarmiento, Rogelio; Rueda-Orgaz, José A
- Abstract
This document summarizes a study on early-onset colorectal cancer (EOCRC) and late-onset colorectal cancer (LOCRC). The study found that there are genetic differences between these two types of colorectal cancer based on the age of onset. Recurrent breakpoints and common fragile sites were identified in both cohorts, and a specific gene, CPEB1, was implicated in EOCRC. Further research is needed to confirm these findings and investigate potential treatment options for EOCRC.
- Subjects
COLORECTAL cancer; TUMOR suppressor genes; CHROMOSOME replication; RECTAL cancer; COLON cancer; RNA polymerase II
- Publication
British Journal of Surgery, 2024, Vol 111, Issue 3, p1
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1093/bjs/znae041