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- Title
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma.
- Authors
Li, Meng; Zhao, Hong; Zhang, Xiaosong; Wood, Laura D.; Anders, Robert A.; Choti, Michael A.; Pawlik, Timothy M.; Daniel, Hubert D.; Kannangai, Rajesh; Offerhaus, G Johan A.; Velculescu, Victor E.; Wang, Linfang; Zhou, Shibin; Vogelstein, Bert; Hruban, Ralph H; Papadopoulos, Nick; Cai, Jianqiang; Torbenson, Michael S.; Kinzler, Kenneth W.
- Abstract
Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype.
- Subjects
UNITED States; EUROPE; CHROMATIN; LIVER cancer; NUCLEOTIDE sequence; HEPATITIS C virus; GENETIC mutation; HEPATITIS B virus; GENETICS
- Publication
Nature Genetics, 2011, Vol 43, Issue 9, p828
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.903