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- Title
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.
- Authors
Miki, Daiki; Kubo, Michiaki; Takahashi, Atsushi; Yoon, Kyong-Ah; Kim, Jeongseon; Geon Kook Lee; Jae Ill Zo; Jin Soo Lee; Hosono, Naoya; Morizono, Takashi; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Chayama, Kazuaki; Takahashi, Takashi; Inazawa, Johji; Nakamura, Yusuke; Daigo, Yataro
- Abstract
Lung cancer is the most common cause of death from cancer worldwide, and its incidence is increasing in East Asian and Western countries. To identify genetic factors that modify the risk of lung adenocarcinoma, we conducted a genome-wide association study in a Japanese cohort, with replication in two independent studies in Japanese and Korean individuals, in a total of 2,098 lung adenocarcinoma cases and 11,048 controls. The combined analyses identified two susceptibility loci for lung adenocarcinoma: TERT (rs2736100, combined P = 2.91 × 10−11, odds ratio (OR) = 1.27) and TP63 (rs10937405, combined P = 7.26 × 10−12, OR = 1.31). Fine mapping of the region containing TP63 showed that a SNP (rs4488809) in intron 1 of TP63 showed the most significant association. Our results suggest that genetic variation in TP63 may influence susceptibility to lung adenocarcinoma in East Asian populations.
- Subjects
EAST Asia; LUNG cancer &; genetics; HUMAN genetic variation; DISEASE incidence; CAUSES of death; DISEASE susceptibility
- Publication
Nature Genetics, 2010, Vol 42, Issue 10, p893
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.667