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- Title
Common variants in WFS1 confer risk of type 2 diabetes.
- Authors
Sandhu, Manjinder S.; Weedon, Michael N.; Fawcett, Katherine A.; Wasson, Jon; Debenham, Sally L.; Daly, Allan; Lango, Hana; Frayling, Timothy M.; Neumann, Rosalind J.; Sherva, Richard; Blech, Ilana; Pharoah, Paul D.; Palmer, Colin N. A.; Kimber, Charlotte; Tavendale, Roger; Morris, Andrew D.; McCarthy, Mark I.; Walker, Mark; Hitman, Graham; Glaser, Benjamin
- Abstract
We studied genes involved in pancreatic β cell function and survival, identifying associations between SNPs in WFS1 and diabetes risk in UK populations that we replicated in an Ashkenazi population and in additional UK studies. In a pooled analysis comprising 9,533 cases and 11,389 controls, SNPs in WFS1 were strongly associated with diabetes risk. Rare mutations in WFS1 cause Wolfram syndrome; using a gene-centric approach, we show that variation in WFS1 also predisposes to common type 2 diabetes.
- Subjects
CELL physiology; GENES; DIABETES risk factors; ENDOCRINE diseases; ASHKENAZIM
- Publication
Nature Genetics, 2007, Vol 39, Issue 8, p951
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng2067