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- Title
A common variant associated with prostate cancer in European and African populations.
- Authors
Amundadottir, Laufey T.; Sulem, Patrick; Gudmundsson, Julius; Helgason, Agnar; Baker, Adam; Agnarsson, Bjarni A.; Sigurdsson, Asgeir; Benediktsdottir, Kristrun R.; Cazier, Jean-Baptiste; Sainz, Jesus; Jakobsdottir, Margret; Kostic, Jelena; Magnusdottir, Droplaug N.; Ghosh, Shyamali; Agnarsson, Kari; Birgisdottir, Birgitta; Le Roux, Louise; Olafsdottir, Adalheidur; Blondal, Thorarinn; Andresdottir, Margret
- Abstract
With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele −8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 × 10−11). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of ∼8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
- Subjects
SWEDEN; ICELAND; UNITED States; PROSTATE cancer; CANCER patients; AFRICAN Americans; GENEALOGY
- Publication
Nature Genetics, 2006, Vol 38, Issue 6, p652
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1808