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- Title
Elevated CD40 Ligand Expressing Blood T-Cell Levels in Multiple Sclerosis Are Reversed by Interferon-Beta Treatment.
- Authors
Teleshova; Bao; Kivisäkk; Özenci; Mustafa; Link
- Abstract
Myelin protein reactive CD4[sup +] T cells are considered to be involved in the proposed immunopathogenesis of multiple sclerosis (MS). One particularly important molecule for T-cell activation is the CD40L (gp39) that is expressed on the surface of T cells. This study focuses on the CD40 and the CD40L expression on mononuclear cells prepared from blood from patients with MS, other neurological diseases (OND) and healthy subjects. Immunostaining followed by a three channel flow cytometry was adopted. Patients with MS had higher levels of CD3[sup +]CD40L[sup +], CD4[sup +]CD40L[sup +] and CD8[sup +]CD40L[sup +] T cells compared to patients with OND and healthy subjects. Cross-sectional comparisons revealed that the elevation of CD40L[sup +] T cell subtypes was confined to the patients with untreated MS and not observed in the patients with MS treated with interferon-β (IFN-β). Follow up studies showed that levels of CD3[sup +]CD40L[sup +] and CD4[sup +]CD40L[sup +] T cells decreased in individual patients after the initiation of the IFN-β treatment. The enhanced expression of CD40L on CD3[sup +], CD4[sup +] and CD8[sup +] T cells in patients with MS may implicate a role for this molecule in disease immunopathogenesis.
- Subjects
MULTIPLE sclerosis; MONOCYTES; B cells; GROWTH
- Publication
Scandinavian Journal of Immunology, 2000, Vol 51, Issue 3
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00688.x