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- Title
Altered Allogeneic Response in Neonatally Anti-MHC Class I-Treated Mice.
- Authors
Marušić-Galešić, S.; Sparbier, K.; Knezevic, N.; Walden, P.
- Abstract
Neonatal treatment of C3H mice (H-2k) with anti-Kk monoclonal antibodies results in altered cytotoxic responses against allogeneic targets. After 2-3 weeks of antibody treatment, no difference in the number of CD4+8- or CD4-8+ T cells was observed between the antibody- and saline-treated mice. However, antibody-treated mice had a significantly reduced cytotoxic response against various allogeneic major histocompatibility complex (MHC) class I-expressing targets. The strongest reduction was observed in very young mice (up to 2 weeks of age). As the mice got older, the allo MHC-specific responses reached control levels. No significant changes in T-cell receptor (TCR)-V-region usage was observed even in young antibody-treated mice. The results suggest that the reduction in the number of positively selecting elements reduces alloreactivity and most likely also the diversity of TCR-repertoire. However, the reduced alloresponsiveness was not restricted to either allogeneic K- or D-encoded molecules, suggesting that self MHC-D-region encoded molecules can mediate positive selection of T cells able to react against both K and D region-encoded allogeneic MHC class I molecules.
- Subjects
MICE; MOLECULES; IMMUNOGLOBULINS; LYMPHOCYTES; T cells; MAJOR histocompatibility complex; MOLECULAR cloning; MONOCLONAL antibodies; IMMUNOLOGICAL tolerance
- Publication
Scandinavian Journal of Immunology, 1996, Vol 43, Issue 3, p321
- ISSN
0300-9475
- Publication type
Article