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- Title
Features of Haemocyanin-Induced Suppression in Vivo.
- Authors
Huchet, R.
- Abstract
Haemocyanin (KLH, 4 mg), given intraperitoneally, induces in mice a state of unresponsiveness related only to the activity of two independent pathways of suppression. The early pathway is characterized by the depression of the anti-trinitrophenyl response to TNP KLH within 24 h of KLH injection, and the ability of spleen cells from KLH-treated animals to transfer unresponsiveness in normal recipients. These features of suppression are stopped after fractionation of spleen cells from KLH-treated mice over insolubilized conjugated histamine columns. The late pathway of suppression is characterized by the nonspecificity of its effector phase, leading to a depressed anti-FLu antibody response after a challenge with TNP KLH + FLu OVA. These features, which are cyclophosphamide-resistant, are no longer active after passage through insolubilized conjugated histamine columns.
- Subjects
LYMPHOID tissue; CELLS; HISTAMINE; ANTIHISTAMINES; IMIDAZOLES; INFLAMMATORY mediators; INFLUENZA; EMBRYOLOGY
- Publication
Scandinavian Journal of Immunology, 1986, Vol 23, Issue 6, p631
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1986.tb01998.x