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- Title
Effect of Histamine Receptor Blocking on Human Antibody-dependent Cell-mediated Cytotoxicity.
- Authors
Láng, I.; Török, K.; Gergely, P.; Nékám, K.; Petrányi, Gy.
- Abstract
The effect of H1 and H3 receptor-blocking agents on antibody-dependent cell-mediated cyto- toxicity (ADCC) was studied. The H1 receptor blocker clemastinum and the H2 receptor blocker cimetidine dose-dependently inhibited the antibody-dependent cytotoxic activity of normal human peripheral blood mononuclear cells on chicken erythrocytes. The inhibition cannot be explained either by a direct toxic effect on effector cells or by blocking of Fc receptors. The possible involvement of histamine receptor-bearing effector cells in human ADCC is suggested.
- Subjects
ANTIBODY-dependent cell cytotoxicity; CELLULAR immunity; CELL receptors; HISTAMINE; INFLAMMATORY mediators; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1981, Vol 13, Issue 4, p361
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00145.x