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- Title
Abnormal body composition in patients with adrenal adenomas.
- Authors
Delivanis, Danae A.; Andrade, Maria D. Hurtado; Cortes, Tiffany; Athimulam, Shobana; Khanna, Aakanksha; Atkinson, Elizabeth; McKenzie, Travis; Takahashi, Naoki; Moynagh, Michael R.; Bancos, Irina
- Abstract
Objective: Increased visceral fat and sarcopenia are cardiovascular risk f actors that may explain increased cardiovascular morbidity and frailty in patients with adrenal a denomas. Our objective was to compare body composition measurement of patients with adrenal adenomas to re ferent subjects without adrenal disease. Design: Cross-sectional study, 2014-2018. Methods: Participants were adults with nonfunctioning adrenal tumor (NFA T), mild autonomous cortisol secretion (MACS), and Cushing syndrome (CS) and age, sex, and BMI 1:1 mat ched referent subjects without adrenal disorders. Main outcome measures were body composition measurements calcul ated from abdominal CT imaging. Intraabdominal adipose tissue and muscle mass measurements were perf ormed at the third lumbar spine level. Results: Of 227 patients with adrenal adenomas, 20 were diagnosed with C S, 76 with MACS, and 131 with NFAT. Median age was 56 years (range: 18-89), and 67% were women. When compa red to referent subjects, patients with CS, MACS, and NFAT demonstrated a higher visceral fat (odds ratio (OR): 2.2 (95% CI: 0.9-6.5), 2.0 (1.3-3.2), and 1.8 (1.2-2.7) and a lower skeletal muscle area (OR: 0.01 (95% CI: 0-0.09), 0.31 (0. 18-0.49), and 0.3 (1.2-2.7)) respectively. For every 1 µg/dL cortisol increase after overnight dexamethasone, viscer al fat/muscle area ratio increased by 2.3 (P = 0.02) and mean total skeletal muscle area decreased by 2.2 cm² (P = 0.03). Conclusion: Patients with adrenal adenomas demonstrate a lower muscle mass and a higher proportion of visceral fat when compared to referent subjects, including patients with NFA T. Even a subtle abnormality in cortisol secretion may impact health of patients with adenomas.
- Subjects
BODY composition; ADENOMA; COMPUTED tomography; CARDIOVASCULAR diseases risk factors; ADULTS; ADRENAL insufficiency; ADRENAL diseases
- Publication
European Journal of Endocrinology, 2021, Vol 185, Issue 5, p653
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-21-0458