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- Title
Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength.
- Authors
Huovinen, Ville; Ivaska, Kaisa K.; Kiviranta, Riku; Bucci, Marco; Lipponen, Heta; Sandboge, Samuel; Raiko, Juho; Eriksson, Johan G.; Parkkola, Riitta; Iozzo, Patricia; Nuutila, Pirjo
- Abstract
Objective: Non-pharmacological interventions are important in reducing risk for osteoporotic fractures. We investigated the effects of a 16-week individualized resistance training intervention on bone mineral density (BMD), bone turnover markers and 10-year relative risk (RR) for osteoporotic fracture. Design: Interventional study with a follow-up. Methods: In total, 37 elderly women (mean age 71.9 ± 3.1 years) with decreased muscle strength participated in the resistance training intervention three times per week with 60 min per session for 16 weeks under the supervision of a licensed physiotherapist. Total hip BMD with quantitative CT, bone markers (sclerostin, osteocalcin, CTX, PINP, IGF-1, 25(OH)-D) and 10-year RR for osteoporotic fracture were measured at baseline, post-intervention and at 1-year follow-up after the end of the intervention. Eleven age- and sex-matched controls did not participate in the intervention but were studied at baseline and at 1-year follow-up. Results: Resistance training seemed to increase total hip BMD by 6% (P = 0.005). Sclerostin (P < 0.001) and total osteocalcin (P = 0.04) increased while other bone markers remained unchanged. A 10-year RR for major osteoporotic and hip fracture remained unchanged. At follow-up total hip BMD (P < 0.001) decreased back to the baseline level with a simultaneous decrease in serum sclerostin (P = 0.045), CTX (P < 0.001) and an increase in 25(OH)-D (P < 0.001), 10-year RR for major osteoporotic (P = 0.002) and hip fracture (P = 0.01). Conclusions: Our findings suggest an important role of continuous supervised resistance training for the prevention of osteoporotic fractures in elderly women with decreased muscle strength.
- Subjects
BONE density; RESISTANCE training; HEALTH of older women; MUSCLE strength; BONE fractures in old age; PREVENTION
- Publication
European Journal of Endocrinology, 2016, Vol 175, Issue 6, p571
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-16-0521