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- Title
Moringa oleifera and Vernonia sp. extracts against Candida albicans and Microsporum canis isolates from dogs and cats and analysis of toxicity to Artemia sp.
- Authors
Gadeiha Roch, Marcos Fábio; de Aguiar, Franscisco Leo Nascimento; Nogueira Brilhante, Raimunda Sâmia; de Aguiar Cordeiro, Rossana; Cordeiro Teixeira, Carlos Eduardo; de Souza Collares Maia Castelo-Branco, Débora; de Araójo Neto Paiva, Manoel; Otaviano Zeferino, João Paulo; Mafezoli, Jair; de Souza Sampaio, Celia Maria; Barbosa, Francisco Geraldo; Costa Sidrim, José Julio
- Abstract
The increase in the incidence of fun gal infections and the frequent report of resistance and therapeutic failure has promoted the performance of phytochen?ical screening for compounds with antifungal properties. Based on this, the present study investigated the antifungal potential of extracts of Baccharis ligustrina, B. schultzii, Croton jacobinensis, Licania rigida, Moringa oleifera, Vernonia sp. and V brasiliana and of essential oils of Lippia alba (Chemotypes 1, 2, 3 and 4) and Ocimum gratissimum. Initially, a qualitative evaluation of the antifungal activity of each vegetal sample against strains of Candida albicans and Microsporum canis, through the agar diffusion method, was performed. Extracts of M. oleifera (MLFC) and Vernonia sp. (TVS-H) presented activity against C. albicans and M. canis with inhibition halos =lOni,n. Then, minimum inhibitory concentrations (MICs) for MLF.C and TVS-H against 12 strains of C. albicans and M. canis were determined through the methodology established by the Clinical and Laboratory Standards Institute (CLSI), and acute toxicity tests against Anemia sp. were performed for both extracts. MICs (80%) for MLF-C and TVS-H varied from 0.156 to 2.5mg mL-1 against C. albicans and from 0.039 to 1.25mg mL-1 and 0.039 to 0.625mg mL-1 against M. canis, respectively. MICs (100%) for MLF-C and TVS-H varied from 0.625 to >2.5mg mL-1 for C. albicans and from 0.039 to 2.5mg mL-1 and 0.078 to / .25mg mL-1 against M. canis, respectively. Lethal doses (DL5) of MLF-C and TVS-H were 201.09 and 204.17mg mL-1, respectively, being, therefore, demonstrated the low toxicity of these extracts. M. oleifera and Vernonia sp. extracts presented in vitro antifungal activity against C. albicans and M. canis, creating perspectives for the development of studies on the characterizations of their bioactive components.
- Subjects
MORINGA oleifera; CANDIDA albicans; MICROSPORUM; ARTEMIA; ANTIFUNGAL agents; ACUTE toxicity testing
- Publication
Ciência Rural, 2011, Vol 41, Issue 10, p1807
- ISSN
0103-8478
- Publication type
Article