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- Title
Developmental neurobiology: implications for pediatric psychopharmacology.
- Authors
Carrey, Normand; Carrey, N
- Abstract
Pediatric psychopharmacology can only be properly understood within the context of developmental neurobiology. Normal maturation of the brain is characterized by the complex anatomic, molecular, and organizational changes required for optimal adaptive functioning. In many areas of the developing nervous system, neurons, cell processes, neurotransmitters, and trophic nerve growth factors are produced in far greater numbers and in different areas than in the mature brain. Psychopathology and stressful environments can lead to enduring changes in brain structure and functioning. A few select psychopharmacological treatments are reviewed to assess their potential impact on CNS development. More clinical and basic science studies are needed to determine whether current treatments have neurotoxic or neuroprotective effects when administered over extended critical early periods of the lifespan.
- Subjects
PSYCHOPHARMACOLOGY; NEUROBIOLOGY; PSYCHIATRIC diagnosis; NEURAL physiology; MENTAL illness drug therapy; BRAIN; DRUGS; MENTAL illness; NERVE growth factor; NEURONS; NEUROTRANSMITTERS; PROGNOSIS; PSYCHIATRIC drugs; SOCIAL context
- Publication
Canadian Journal of Psychiatry, 2001, Vol 46, Issue 9, p810
- ISSN
0706-7437
- Publication type
journal article
- DOI
10.1177/070674370104600904