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- Title
Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer's Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age.
- Authors
Wei, Zhang; Li, Daidi; Shi, Jingshan
- Abstract
Alzheimer's disease (AD) is a progressive neurological disease. Gut microbial dysbiosis is associated with AD. This study involves the comparative assessment of spatial learning, β-amyloid peptide accumulation, and fecal microbiota alterations in 3×Tg-AD mice from 3 age groups: AD asymptomatic stage (3 m), presymptomatic stage (6 m), and the symptomatic stage of AD (9 m). We demonstrate that spatial memory deficits, brain Aβ accumulation, and weight gain in 3×Tg-AD mice gradually appear after 6 months of age. However, the total gut bacterial counts underwent changes from 3 to 6 months of age and were further altered at 9 months of age. Importantly, changes in gut bacteria abundance of Desulfobacterota and Actinobacteriota phyla in 6-month-old mice preceded apparent spatial memory deficits. In summary, Changes in the gut microbial community are one of the mechanisms of early AD pathology.
- Subjects
MEMORY; STATISTICS; ALZHEIMER'S disease; SEQUENCE analysis; DNA; STAINS &; staining (Microscopy); ANALYSIS of variance; GUT microbiome; ANIMAL experimentation; IMMUNOHISTOCHEMISTRY; AMYLOID beta-protein precursor; WEIGHT gain; T-test (Statistics); DESCRIPTIVE statistics; RESEARCH funding; DATA analysis; DATA analysis software; MICE
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2023, Vol 38, p1
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/15333175231174193