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- Title
Chromosomal polymorphisms associated with reproductive outcomes after IVF-ET.
- Authors
Li, Sai-jiao; Cheng, Yan-xiang; Ye-Shang; Zhou, Dan-ni; Zhang, Yin; Yin, Tai-lang; Yang, Jing
- Abstract
Purpose: This study aimed to investigate the effect of the detail type of chromosomal polymorphisms (1/9/16qh+/−, D/G group polymorphisms, and inv(9)) on the IVF-ET outcomes. Methods: A total of 1335 infertile couples undergoing IVF/ICSI were enrolled and comprehensively analyzed the correlation between three detail types of chromosomal polymorphisms (1/9/16qh+/−, D/G group polymorphisms, and inv(9)) and the outcome of IVF/ICSI embryo transfer. The fertilized rate, cleaved embryo rate, good-quality embryo rate, clinical pregnancy rate, implantation rate, and early stage miscarriage rate were compared between the chromosomal polymorphisms groups and the control group. Results: Both the inv(9) and D/G group chromosomal polymorphisms related to female infertility significantly lead to a lower 2PN cleavage rate (86.44% vs. 97.58% and 90.67% vs. 97.58%, respectively, P < 0.05) undergoing IVF insemination, the inv(9) adversely increasing the early miscarriage rate, either undergoing IVF (21.4% vs. 3.0%, P < 0.05) or ICSI (50.0% vs. 2.0%, P < 0.05) insemination, female carriers (23.08% vs. 2.87%, P < 0.05) or male carriers (44.44% vs. 2.87%, P < 0.05). For D/G groups, ICSI insemination may increase the implantation rate (44.8% vs. 23.69%, P < 0.05) and clinical pregnancy rate (78.6% vs. 40.65%, P < 0.05). 1/9/16qh+/− had no apparent adverse effect on the patient's clinical outcomes. Conclusions: Our study suggests that chromosome karyotype analysis is necessary for IVF patients in clinical practice; we should afford individual genetic counseling suggestion according to the polymorphism types.
- Subjects
HUMAN embryo transfer; HUMAN in vitro fertilization; KARYOTYPES; COUNSELING; FEMALE infertility; GENETIC counseling; CHROMOSOME analysis; EMBRYO transfer
- Publication
Journal of Assisted Reproduction & Genetics, 2020, Vol 37, Issue 7, p1703
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-020-01793-8