We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chromosomal polymorphisms are independently associated with multinucleated embryo formation.
- Authors
Sun, Ling; Chen, Zhi-Heng; Yang, Li; Yi, Cui-Xing; Liu, Jun; Ou, Chun-Quan
- Abstract
Purpose: The purpose of this study is to explore the factors associated with embryo multinucleation, particularly focused on the influence of parental chromosomal polymorphisms in embryo multinucleation. Methods: This is a retrospective case-control study involving 1260 infertile couples undergoing their first IVF/ICSI cycles. Couples were screened for abnormalities in their karyotype and were evaluated for blastomere persistence of multinucleation. Demographic characteristics, stimulation protocol, and pregnant outcomes were analyzed using logistic regression analysis. Results: The level of basal FSH was lower in the multinucleated embryos group (5.37 vs 5.72 IU/L). The Multinucleated embryos group received less gonadotropins (1788.5 vs 1891.3 IU), and the level of LH on day of HCG triggering was lower (1.09 vs 1.30 IU/L). More oocytes were recovered in the multinucleated embryos group (11.51 vs 9.23). Chromosomal polymorphisms were seen in at least 1 out of 163 (12.9%) couples. Multivariate logistic regression analysis revealed that chromosomal polymorphisms were independently associated with an increase in the occurrence risk of multinucleated embryos (OR = 1.61, 95% CI, 1.06-2.44) in the first IVF/ICSI cycle. The miscarriage rate in the multinucleated embryos group was 10% higher than that of the control group. Conclusions: Chromosomal polymorphisms were independently associated with multinucleation embryo formation. A higher LH level on the day of HCG triggering was associated with a decreased chance of multinucleation.
- Subjects
CHROMOSOME abnormalities; GENETIC polymorphisms; HUMAN embryo transfer; HUMAN in vitro fertilization; KARYOTYPES
- Publication
Journal of Assisted Reproduction & Genetics, 2018, Vol 35, Issue 1, p149
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-017-1037-9