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- Title
The predictive value of anti-mullerian hormone on embryo quality, blastocyst development, and pregnancy rate following in vitro fertilization-embryo transfer (IVF-ET).
- Authors
Lin, Wen-Qin; Yao, Ling-Nv; Zhang, Dong-Xue; Zhang, Wei; Yang, Xiao-Jing; Yu, Rong
- Abstract
Purpose: The objective of this study was to investigate the predictive value of anti-Mullerian hormone (AMH) on fertilization rate (FR), blastocyst development, embryo quality, the outcome of the pregnancy and the live birth rate (LBR) following in vitro fertilization-embryo transfer (IVF-ET)/intracytoplasmic sperm injection (ICSI). Method: In this prospective study outcomes were followed in 83 women undergoing cycles of IVF/ICSI within a university hospital. Basal serum AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH) and antral follicle count (AFC) were measured on Day 3. Serum AMH (Gn6 AMH ) level was measured on Day 6 after the administration of gonadotrophin (Gn). AMH was measured in follicle fluid (FF AMH) on the day of ovum pick-up (dOPU). The numbers of retrieved and fertilized oocytes, good quality embryos and blastocysts were counted. Secondary outcome variables included clinical pregnancy rate (CPR) and LBR. Results: Spearman correlation analysis indicated that the numbers of oocytes, good quality embryos and blastocysts were associated with AMH ( P < 0.05) and that LBR was correlated with FF AMH ( r = 0.495, P < 0.05). No associations were found between FR and AMH ( P > 0.05). Receiver operating characteristic analysis showed that the sensitivity of FF AMH at predicting CPR was 91.2 %; the specificity was 86.5 % and ROC was 0.893 ( P < 0.0001). Conclusion: AMH parameters were correlated with good quality embryos and blastocysts, but only FF AMH showed a significant correlation with LBR and CPR.
- Subjects
FERTILIZATION in vitro; EMBRYO transfer; ANTI-Mullerian hormone; PREGNANCY complications; EMBRYOS; BLASTOCYST; LUTEINIZING hormone
- Publication
Journal of Assisted Reproduction & Genetics, 2013, Vol 30, Issue 5, p649
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-013-9973-5