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- Title
Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles.
- Authors
Barker, Matthew A.; Boehnlein, Lynn M.; Kovacs, Peter; Lindheim, Steven R.
- Abstract
Purpose To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes. Methods Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist downregulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer. Results Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes. Conclusions Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.
- Subjects
ORGAN donation; OVUM donation; PREGNANCY; LUTEAL phase; MENSTRUAL cycle; BLASTOCYST
- Publication
Journal of Assisted Reproduction & Genetics, 2009, Vol 26, Issue 5, p243
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-009-9312-z