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- Title
Vasodilator Effect of Endothelin in Cutaneous Microcirculation of Heart Failure Patients.
- Authors
Andersson, Sven E.; Edvinsson, Marie-Louise; Alving, Kjell; Edvinsson, Lars
- Abstract
The heart failure syndrome is associated with a reduced vasodilatory capacity in cutaneous microvessels. The aim of this study was to investigate the hypothesis that an altered activity of the endothelin system contributes to this reduction. The skin blood flow was recorded by laser Doppler flowmetry in patients with congestive heart failure and in age- and gender-matched controls without clinical signs of heart failure. The vessels were stimulated by iontophoretic administration of endothelin-1. The involvement of the endothelinA receptor was studied by co-administration of a specific antagonist; the role of the endothelinB receptor was studied by the administration of the selective agonist sarafotoxin 6c. The plasma levels of endothelin-1, C-reactive peptide and N-terminal-pro-Brain Natriuretic Peptide were elevated in heart failure patients. Unexpected, endothelin-1 induced an endothelinA mediated vasodilation. In the heart failure group the dilation was reduced to less than half as compared to control. The response to local warming was reduced in parallel indicating that the attenuation of the response in the heart failure group can be explained by the general decline in vascular reactivity. The response to endothelinB receptor stimulation did not differ between the groups. The reduction in endothelin-1 responsiveness is paralleled by a general reduction in microvascular vasodilatory capacity, a phenomenon of increased vascular stiffness in the of heart failure subjects.
- Subjects
CONGESTIVE heart failure; VASODILATION; ENDOTHELINS; IONTOPHORESIS; MICROCIRCULATION; PEPTIDES
- Publication
Basic & Clinical Pharmacology & Toxicology, 2005, Vol 97, Issue 2, p80
- ISSN
1742-7835
- Publication type
Article
- DOI
10.1111/j.1742-7843.2005.pto_84.x