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- Title
Direct Enamido C(sp<sup>2</sup>)−H Diphosphorylation Enabled by a PCET‐Triggered Double Radical Relay: Access to gem‐Bisphosphonates.
- Authors
Cao, Hao‐Qiang; Liu, Hao‐Nan; Liu, Zhe‐Yuan; Qiao, Bao‐Kun; Zhang, Fa‐Guang; Ma, Jun‐An
- Abstract
Herein we report a novel and straightforward protocol for the construction of valuable gem‐BPs by means of proton‐coupled electron‐transfer (PCET)‐triggered enamido C(sp2)−H diphosphorylation. This reaction represents a rare example of realizing the challenging double C−P bond formation at a single carbon atom, thus providing facile access to a broad variety of structurally diverse bisphosphonates from simple enamides under silver‐mediated conditions. Initial mechanistic studies demonstrated that the diphosphorylation involves two rounds of PCET‐initiated radical relay process.
- Subjects
DOUBLE bonds; DIPHOSPHONATES
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 24, p5515
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202000517