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- Title
Rücktitelbild: Rapid and Bifunctional Chemoselective Metabolome Analysis of Liver Disease Plasma Using the Reagent 4‐Nitrophenyl‐2H‐azirine (Angew. Chem. 14/2024).
- Authors
Lin, Weifeng; Gerullat, Lars; Braadland, Peder R.; Fournier, Anaïs; Hov, Johannes R.; Globisch, Daniel
- Abstract
A recent article in Angewandte Chemie describes a new method for rapidly analyzing the metabolome of plasma in liver disease patients. The method involves using a reagent called 4-nitrophenyl-2H-azirine to convert metabolic carboxylic acids into a new ketone within 10 minutes. The ketone is then quantified using a chemical probe methodology called Quant-SCHEMA. This new bifunctional methodology has potential applications in biomarker discovery and metabolomics. The authors of the article are Daniel Globisch et al.
- Subjects
CHEMICAL biology; BAIT fishing; KETONIC acids; BAITFISH; FISHING baits
- Publication
Angewandte Chemie, 2024, Vol 136, Issue 14, p1
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202403082